Tg(CAG-ELN*)60Zu
Transgene Detail

Summary

• Symbol: Tg(CAG-ELN*)60Zu
• Name: transgene insertion 60, Zsolt Urban
• MGI ID: MGI:4867517
• Synonyms: CL mice
• Transgene: Tg(CAG-ELN*)60Zu Location: unknown
• Alliance: Tg(CAG-ELN*)60Zu page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-ELN*)60Zu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ELN (2006)

  Eln	(MGI:95317)

• Mutation details: A cytomegalovirus immediate-early enhancer and a chicken beta actin promoter drive the expression of a mutant human elastin cDNA, an internal ribosomal entry site (IRES) and an EGFP cDNA. The mutation in human elastin is based on the major mRNA isoform in a family with autosomal dominant cutix laxa caused by a 25 base pair deletion, 2114_2138del, located in exon 30 of the elastin gene. This frameshift mutation, which is frequently subject to removal by normally occurring alternative splicing, results in the replacement of the C-terminus of tropoelastin by a missense peptide sequence of 81 amino acids. (J:166809)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:166809 Hu Q, et al., Mechanisms of emphysema in autosomal dominant cutis laxa. Matrix Biol. 2010 Sep;29(7):621-8
• All: 1 reference(s)