Fbxw7^tm1.1Axbe
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1.1Axbe
• Name: F-box and WD-40 domain protein 7; targeted mutation 1.1, Axel Behrens
• MGI ID: MGI:4867641
• Synonyms: Fbxw7^f
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1.1Axbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 5. (J:166928)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:166928 Hoeck JD, et al., Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci. 2010 Nov;13(11):1365-72
• All: 21 reference(s)