Rest^tm1.1Whk
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.1Whk
• Name: RE1-silencing transcription factor; targeted mutation 1.1, William H Klein
• MGI ID: MGI:4867679
• Synonyms: REST^fx
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.1Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167071
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxC2 site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxC2 site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:167071)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 96 strains or lines available

References

• Original: J:167071 Mao CA, et al., Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 1;349(1):90-9
• All: 4 reference(s)