Prkd2^tm1.1Daca
Targeted Allele Detail

Summary

• Symbol: Prkd2^tm1.1Daca
• Name: protein kinase D2; targeted mutation 1.1, Doreen A Cantrell
• MGI ID: MGI:4867730
• Synonyms: PKD2(S707A/S711A), PKD2^SSAA
• Gene: Prkd2 Location: Chr7:16576827-16604386 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Prkd2^tm1.1Daca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166867
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 16 was replaced with one containing nucleotide substitutions that result in the amino acid substitution of alanine for serine at positions 707 and 711 (S707A, S711A). A floxed neo cassette inserted downstream of the modified exon 16 was removed by cre-mediated recombination. (J:166867)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkd2 Mutation: 41 strains or lines available

References

• Original: J:166867 Matthews SA, et al., Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells. Biochem J. 2010 Oct 25;432(1):153-63
• All: 7 reference(s)