Tg(Slc32a1-cre)2.1Hzo
Transgene Detail

Summary

• Symbol: Tg(Slc32a1-cre)2.1Hzo
• Name: transgene insertion 2.1, Huda Y Zoghbi
• MGI ID: MGI:4867735
• Synonyms: Tg2.1, Viaat-Cre
• Transgene: Tg(Slc32a1-cre)2.1Hzo Location: unknown
• Alliance: Tg(Slc32a1-cre)2.1Hzo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc32a1-cre)2.1Hzo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc32a1 (MGI:1194488)

• Mutation details: BAC RP23-392P11 containing the Slc32a1 (Viaat) locus was modified by homologous recombination by inserting a Cre-recombinase sequence followed by a stop codon and a polyadenylation sequence downstream of the start codon of the Slc32a1 (or Viaat) gene. After linearization, the BAC only contained Viaat and the truncated coding sequence of the actin-related protein 5 homolog (Actr5) gene. This modified 109 kb BAC was microinjected into fertilized FVB/N oocytes. Transgenic animals have similar expression levels of Slc32a1 and Actr5 to wild type mice. Founder line 2.1 was analyzed and propagated. (J:166851)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc32a1 (mouse) Summary of all recombinase alleles driven by Slc32a1. Alliance mouse Slc32a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:166851 Chao HT, et al., Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11;468(7321):263-9
• All: 32 reference(s)