Aip^tm2.1Bra
Targeted Allele Detail

Summary

• Symbol: Aip^tm2.1Bra
• Name: aryl-hydrocarbon receptor-interacting protein; targeted mutation 2.1, Christopher A Bradfield
• MGI ID: MGI:4867825
• Synonyms: Aip^fx
• Gene: Aip Location: Chr19:4164446-4175858 bp, - strand Genetic Position: Chr19, 3.82 cM
• Alliance: Aip^tm2.1Bra page

Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice are resistant to dioxin-induced hepatic damage

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette leaving exons 3 through 6 floxed. This allele was used to generate Aip^tm1Bra. (J:141575)

Generation of the Aip^tm2.1Bra allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aip Mutation: 26 strains or lines available

References

• Original: J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32
• All: 2 reference(s)