Aip^tm2Bra
Targeted Allele Detail

Summary

• Symbol: Aip^tm2Bra
• Name: aryl-hydrocarbon receptor-interacting protein; targeted mutation 2, Christopher A Bradfield
• MGI ID: MGI:4867827
• Synonyms: Ara9^fxneo
• Gene: Aip Location: Chr19:4164446-4175858 bp, - strand Genetic Position: Chr19, 3.82 cM
• Alliance: Aip^tm2Bra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141575
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. Reduced protein expression was confirmed by western blot analysis on heart, liver, kidney, spleen, and thymus extracts. This allele is hypomorphic. (J:141575)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aip Mutation: 26 strains or lines available

References

• Original: J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32
• All: 3 reference(s)