E4f1^tm1.1Llca
Targeted Allele Detail

Summary

• Symbol: E4f1^tm1.1Llca
• Name: E4F transcription factor 1; targeted mutation 1.1, Laurent Le Cam
• MGI ID: MGI:4867860
• Synonyms: E4F1^flox
• Gene: E4f1 Location: Chr17:24662752-24674366 bp, - strand Genetic Position: Chr17, 12.39 cM
• Alliance: E4f1^tm1.1Llca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167157
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a second loxP site followed by an FRT flanked hygromycin thymidine kinase cassette were inserted downstream of exon 14 via homologous recombination. Flp mediated recombination removed the hygromycin thymidine kinase cassette. (J:167157)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any E4f1 Mutation: 38 strains or lines available

References

• Original: J:167157 Lacroix M, et al., Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21076-81
• All: 5 reference(s)