Pfdn5^nmf5a
Chemically induced Allele Detail

Summary

• Symbol: Pfdn5^nmf5a
• Name: prefoldin 5; neuroscience mutagenesis facility 5a
• MGI ID: MGI:4867864
• Synonyms: nmf5a
• Gene: Pfdn5 Location: Chr15:102234551-102239925 bp, + strand Genetic Position: Chr15, 57.48 cM
• Alliance: Pfdn5^nmf5a page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition that results in the amino acid substitution of arginine for leucine at position 110 (L110R). This mutation is predicted to affect the flexibility of the tentacles through which the substrate is accommodated in the interior cavity. (J:167349)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pfdn5 Mutation: 20 strains or lines available

References

• Original: J:167349 Lee Y, et al., Prefoldin 5 is required for normal sensory and neuronal development in a murine model. J Biol Chem. 2011 Jan 7;286(1):726-36
• All: 3 reference(s)