Trpm1^tvrm27
Chemically induced Allele Detail

Summary

• Symbol: Trpm1^tvrm27
• Name: transient receptor potential cation channel, subfamily M, member 1; translational vision research model 27
• MGI ID: MGI:4867880
• Gene: Trpm1 Location: Chr7:63803583-63919523 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Trpm1^tvrm27 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Dominant negative)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A point mutation that results in the amino acid substitution of threonine for alanine at position 1068 (A1068T). Immunohistochemistry confirmed normal expression and localization of the protein product. However, channel function is lost. (J:209941)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpm1 Mutation: 101 strains or lines available

References

• Original: J:166679 Won J, et al., Mouse model resources for vision research. J Ophthalmol. 2011;2011:391384
• All: 3 reference(s)