Pde6a^tvrm58
Chemically induced Allele Detail

Summary

• Symbol: Pde6a^tvrm58
• Name: phosphodiesterase 6A, cGMP-specific, rod, alpha; translational vision research model 58
• MGI ID: MGI:4867884
• Gene: Pde6a Location: Chr18:61353387-61422995 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pde6a^tvrm58 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a point mutation (T to C) that results in the amino acid substitution of proline for leucine at position 638 (L638P) within the conserved metal dependent phosphohydrolase HD domain. (J:166679, J:214072)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pde6a Mutation: 52 strains or lines available

References

• Original: J:166679 Won J, et al., Mouse model resources for vision research. J Ophthalmol. 2011;2011:391384
• All: 3 reference(s)