Rassf5^tm1Sblee
Targeted Allele Detail

Summary

• Symbol: Rassf5^tm1Sblee
• Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Sean Lee
• MGI ID: MGI:4868223
• Synonyms: Noer1^-
• Gene: Rassf5 Location: Chr1:131104147-131172915 bp, - strand Genetic Position: Chr1, 56.91 cM
• Alliance: Rassf5^tm1Sblee page

Rassf5^tm1Sblee/Rassf5^tm1Sblee mice are resistant to TNF-alpha-induced apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166871
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Exons 3, 4, and 5 were replaced with a floxed neomycin resistance cassette. (J:166871)

Generation of the Rassf5^tm1Sblee allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rassf5 Mutation: 26 strains or lines available

References

• Original: J:166871 Park J, et al., Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 5;285(45):35029-38
• All: 3 reference(s)