Alkbh1^tm1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh1^tm1Klng
• Name: alkB homolog 1, histone H2A dioxygenase; targeted mutation 1, Arne Klungland
• MGI ID: MGI:4868224
• Gene: Alkbh1 Location: Chr12:87474847-87490609 bp, - strand Genetic Position: Chr12, 41.65 cM
• Alliance: Alkbh1^tm1Klng page

Eye and skeletal abnormalities in Alkbh1^tm1Klng/Alkbh1^tm1Klng embryos and newborns

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166841
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 6 was replaced with a neo cassette, removing the conserved 2-oxoglutarate interaction domain (RvNmTvR) and parts of the iron-binding cluster (HvD...H) essential for enzymatic activity. (J:166841)

Expression

In Mice Carrying this Mutation:	23 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh1 Mutation: 19 strains or lines available

References

• Original: J:166841 Nordstrand LM, et al., Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010;5(11):e13827
• All: 3 reference(s)