Mirc19^tm1.1Kcho
Targeted Allele Detail

Summary

• Symbol: Mirc19^tm1.1Kcho
• Name: microRNA cluster 19, including Mir212 through Mir132; targeted mutation 1.1, Kamal Chowdhury
• MGI ID: MGI:4868242
• Synonyms: miR-212/132^-, Mir212-Mir132^ILN, Mir212/Mir132^tm1.1Kcho
• Gene: Mirc19 Location: Chr11:75064214-75064573 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166674
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The region encoding both Mir212 and Mir132 was replaced with an IRES, lacZ, and an FRT site flanked neomycin resistance gene cassette. Subsequent flp-mediated recombination removed the neo cassette. (J:166674)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc19 Mutation: 0 strains or lines available

References

• Original: J:166674 Ucar A, et al., miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat Genet. 2010 Dec;42(12):1101-8
• All: 10 reference(s)