Flot1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Flot1^tm1.1Arte
• Name: flotillin 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:4868388
• Gene: Flot1 Location: Chr17:36134243-36143674 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Flot1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 8. Cre-mediated recombination removed exons 3 through 8 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:166672)

Generation of the Flot1^tm1.1Arte allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flot1 Mutation: 18 strains or lines available

References

• Original: J:166672 Ludwig A, et al., Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol. 2010 Nov 15;191(4):771-81
• All: 5 reference(s)