Mmp15^tm1Kohl
Targeted Allele Detail

Summary

• Symbol: Mmp15^tm1Kohl
• Name: matrix metallopeptidase 15; targeted mutation 1, Kenn Holmbeck
• MGI ID: MGI:4868411
• Gene: Mmp15 Location: Chr8:96078924-96100921 bp, + strand Genetic Position: Chr8, 47.12 cM
• Alliance: Mmp15^tm1Kohl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167396
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 through exon 5 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on embryo extracts. (J:167396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp15 Mutation: 38 strains or lines available

References

• Original: J:167396 Szabova L, et al., Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
• All: 1 reference(s)