Mmp14^tm1.1Khol
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1.1Khol
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1.1, Kenn Holmbeck
• MGI ID: MGI:4868413
• Synonyms: MT1-MMP^LoxP
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1.1Khol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette leaving exons 2 through 5 floxed. (J:167396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 44 strains or lines available

References

• Original: J:167396 Szabova L, et al., Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
• All: 3 reference(s)