Ptpn11^tm3Bgn
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm3Bgn
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 3, Benjamin G Neel
• MGI ID: MGI:4868451
• Synonyms: Shp2^fl
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm3Bgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88290
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 11 was floxed. (J:88290)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 46 strains or lines available

References

• Original: J:88290 Zhang SQ, et al., Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell. 2004 Feb 13;13(3):341-55
• All: 26 reference(s)