Del(10Prmt2-Col6a1)1Yah
Targeted Allele Detail

Summary

• Symbol: Del(10Prmt2-Col6a1)1Yah
• Name: deletion, Chr 10, Yann Herault 1
• MGI ID: MGI:4868462
• Synonyms: Del(10Col6a1-Prmt2)Yah, Del(10Prmt2-Col6a1)3Yah, Ms1Yah
• Gene: Del(10Prmt2-Col6a1)1Yah Location: Chr10:76043060-76561878 bp Genetic Position: Chr10, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167506
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(10Prmt2-Col6a1)1Yah involves 19 genes/genome features (Gm22441, Prmt2, Mir678 ...) View all
• Mutation details: These mice were created using MICER targeting vectors. Prmt2 was targeted using a vector selected from the 3' HPRT library and the Col6a1 locus in cis was targeted using a vector selected from the 5' HPRT library. Mice carrying this construct were crossed with Tg(CMV-cre)1Ipc transgenic mice. Cre expression results in excision of a 0.5 MB segment of chromosome 10 containing 13 genes, 9 withknown functions. (J:167506)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(10Prmt2-Col6a1)1Yah Mutation: 1 strain or line available

References

• Original: J:167506 Besson V, et al., Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses. Hum Mol Genet. 2007 Sep 1;16(17):2040-52
• All: 2 reference(s)