Cflar^tm1.2Pope
Targeted Allele Detail

Summary

• Symbol: Cflar^tm1.2Pope
• Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1.2, Richard M Pope
• MGI ID: MGI:4868693
• Synonyms: Flip^d
• Gene: Cflar Location: Chr1:58750667-58798043 bp, + strand Genetic Position: Chr1, 29.16 cM
• Alliance: Cflar^tm1.2Pope page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167430
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted just upstream of exon 2 (containing the ATG start codon). A floxed neomycin resistance cassette was also inserted in intron 3. The resistance cassette was removed prior to blastocyst injection, presumably by transient cre excision. This left exons 2 and 3 flanked by loxP sites. Miced with this floxed allele were then crossed to mice carrying a Zp3-cre transgene to produce the deleted allele. (J:167430)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cflar Mutation: 32 strains or lines available

References

• Original: J:167430 Huang QQ, et al., FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood. 2010 Dec 2;116(23):4968-77
• All: 1 reference(s)