Hes1tm1.1Frad
Targeted Allele Detail
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Symbol: |
Hes1tm1.1Frad |
Name: |
hes family bHLH transcription factor 1; targeted mutation 1.1, Freddy Radtke |
MGI ID: |
MGI:4868726 |
Synonyms: |
Hes1lox |
Gene: |
Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
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Alliance: |
Hes1tm1.1Frad page
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Germline Transmission: |
Earliest citation of germline transmission:
J:167000
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: Tow loxP sites were inserted to flank part of intron 1, exons 2-4 and the 3'UTR. An FRT site-flanked neomycin resistance gene was introduced followed by the second loxP site, and removed later by Flp-mediated recombination. A beta-galactosidase gene was also inserted after the second loxP site. Cre-mediated recombination of the loxP-flanked gene segment creates an in frame translation of beta-galactosidase.
(J:167000)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hes1 Mutation: |
23 strains or lines available
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Original: |
J:167000 Wendorff AA, et al., Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity. 2010 Nov 24;33(5):671-84 |
All: |
1 reference(s) |
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