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Hes1tm1.1Frad
Targeted Allele Detail
Summary
Symbol: Hes1tm1.1Frad
Name: hes family bHLH transcription factor 1; targeted mutation 1.1, Freddy Radtke
MGI ID: MGI:4868726
Synonyms: Hes1lox
Gene: Hes1  Location: Chr16:29883259-29886614 bp, + strand  Genetic Position: Chr16, 21.09 cM
Alliance: Hes1tm1.1Frad page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167000
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsTow loxP sites were inserted to flank part of intron 1, exons 2-4 and the 3'UTR. An FRT site-flanked neomycin resistance gene was introduced followed by the second loxP site, and removed later by Flp-mediated recombination. A beta-galactosidase gene was also inserted after the second loxP site. Cre-mediated recombination of the loxP-flanked gene segment creates an in frame translation of beta-galactosidase. (J:167000)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hes1 Mutation:  23 strains or lines available
References
Original:  J:167000 Wendorff AA, et al., Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity. 2010 Nov 24;33(5):671-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory