Dmbt1^tm2Qaa
Targeted Allele Detail

Summary

• Symbol: Dmbt1^tm2Qaa
• Name: deleted in malignant brain tumors 1; targeted mutation 2, Qais Al-Awqati
• MGI ID: MGI:4868734
• Gene: Dmbt1 Location: Chr7:130633787-130723357 bp, + strand Genetic Position: Chr7, 73.2 cM, cytoband F4
• Alliance: Dmbt1^tm2Qaa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167156
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A loxP site was inserted upstream of exon 1 and an FRT- and loxP-flanked neo cassette. (J:167156)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmbt1 Mutation: 111 strains or lines available

References

• Original: J:167156 Gao X, et al., Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21872-7
• All: 1 reference(s)