Fto^tm1.1Pzg
Targeted Allele Detail

Summary

• Symbol: Fto^tm1.1Pzg
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.1, Pumin Zhang
• MGI ID: MGI:4868738
• Synonyms: Fto^flox
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^tm1.1Pzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166984
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, and an FRT-flanked neo cassette with a 5' loxP site was inserted dowstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exon 3 floxed. (J:166984)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 75 strains or lines available

References

• Original: J:166984 Gao X, et al., The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5(11):e14005
• All: 12 reference(s)