Fto^tm1.3Pzg
Targeted Allele Detail

Summary

• Symbol: Fto^tm1.3Pzg
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.3, Pumin Zhang
• MGI ID: MGI:4868745
• Synonyms: Fto^*delta
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^tm1.3Pzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166984
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of the original intergration removed exon 3 leaving the FRT-flanked neo cassette intact. The absence of protein expression was confirmed by western blot analysis on brain, white adipose tissue, and brown adipose tissue. (J:166984)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 75 strains or lines available

References

• Original: J:166984 Gao X, et al., The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5(11):e14005
• All: 2 reference(s)