Atmin^tm1Axbe
Targeted Allele Detail

Summary

• Symbol: Atmin^tm1Axbe
• Name: ATM interactor; targeted mutation 1, Axel Behrens
• MGI ID: MGI:4868760
• Synonyms: ATMIN^F
• Gene: Atmin Location: Chr8:117670132-117687184 bp, + strand Genetic Position: Chr8, 63.37 cM
• Alliance: Atmin^tm1Axbe page

Decreased body size and reduced dopaminergic neurons in Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. (J:167331)

Generation of the Atmin^tm1Axbe allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atmin Mutation: 38 strains or lines available

References

• Original: J:167331 Kanu N, et al., The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010 Dec 3;285(49):38534-42
• All: 6 reference(s)