App^tm2.1Ldad
Targeted Allele Detail

Summary

• Symbol: App^tm2.1Ldad
• Name: amyloid beta precursor protein; targeted mutation 2.1, Luciano D'Adamio
• MGI ID: MGI:4868765
• Synonyms: App^Y682G, APP YG
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm2.1Ldad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 16 was replaced with a floxed neo cassette and a modified exon 16 in which a point mutations (TAT to GGA) results in the amino acid substitution of glycine for tyrosine at position 682 (Y682G). Cre-mediated recombination removed the neo cassette. (J:166989)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:166989 Barbagallo AP, et al., Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One. 2010;5(11):e15503
• All: 4 reference(s)