Mdga1^tm1.1Tymo
Targeted Allele Detail

Summary

• Symbol: Mdga1^tm1.1Tymo
• Name: MAM domain containing glycosylphosphatidylinositol anchor 1; targeted mutation 1.1, Toru Yamamoto
• MGI ID: MGI:4878863
• Synonyms: Mdga1^LacZ
• Gene: Mdga1 Location: Chr17:30046930-30107557 bp, - strand Genetic Position: Chr17, 15.54 cM, cytoband B1
• Alliance: Mdga1^tm1.1Tymo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166980
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ and FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on E15.5 and P14 brain extracts. (J:166980)

Expression

In Mice Carrying this Mutation:

131 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mdga1 Mutation: 97 strains or lines available

References

• Original: J:166980 Ishikawa T, et al., IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Dev Dyn. 2011 Jan;240(1):96-107
• All: 4 reference(s)