Tert^tm2.1Rdp
Targeted Allele Detail

Summary

• Symbol: Tert^tm2.1Rdp
• Name: telomerase reverse transcriptase; targeted mutation 2.1, Ronald DePinho
• MGI ID: MGI:4878865
• Synonyms: TERT-ER
• Gene: Tert Location: Chr13:73775030-73797962 bp, + strand Genetic Position: Chr13, 40.12 cM
• Alliance: Tert^tm2.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An ERT2 ligand binding domain was inserted upstream and in-frame of exon 1, and a floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette. (J:167227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tert Mutation: 55 strains or lines available

References

• Original: J:167227 Jaskelioff M, et al., Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 6;469(7328):102-6
• All: 4 reference(s)