Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ulrich Boehm
• MGI ID: MGI:4878874
• Synonyms: eR26-tauGFP, ROSA26-CAGS-tGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167285
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A construct with the CAGS promoter driving expression of a Mapt/GFP (tau/GFP) fusion protein upon cre-mediated excision of a STOP sequence, was knocked into the Gt(ROSA)26Sor locus. (J:167285, J:173865)

Expression

In Mice Carrying this Mutation:

132 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:167285 Mayer C, et al., Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22693-8
• All: 41 reference(s)