Fli1^tm1.1Morl
Targeted Allele Detail

Summary

• Symbol: Fli1^tm1.1Morl
• Name: Friend leukemia integration 1; targeted mutation 1.1, Francois Morle
• MGI ID: MGI:4878922
• Synonyms: Fli-1^delta
• Gene: Fli1 Location: Chr9:32333500-32454157 bp, - strand Genetic Position: Chr9, 17.74 cM
• Alliance: Fli1^tm1.1Morl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167426
• Parent Cell Line: ENS (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two loxP sites were inserted flanking the coding sequence of exon 9 which contains the whole ETS DNA binding and C-terminal domains. This was followed by an FRT flanked neomycin resistance cassette. The selection cassette was subsequenty excised by transient flp expression. Exon 9 was then excised in the germline by cre expression. (J:167426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fli1 Mutation: 26 strains or lines available

References

• Original: J:167426 Starck J, et al., Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood. 2010 Dec 2;116(23):4795-805
• All: 1 reference(s)