Cxcr4^tm3.1Yzo
Targeted Allele Detail

Summary

• Symbol: Cxcr4^tm3.1Yzo
• Name: C-X-C motif chemokine receptor 4; targeted mutation 3.1, Yong-Rui Zou
• MGI ID: MGI:4878934
• Synonyms: CXCR4^deltaT
• Gene: Cxcr4 Location: Chr1:128515936-128520030 bp, - strand Genetic Position: Chr1, 56.43 cM
• Alliance: Cxcr4^tm3.1Yzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette and exon 2. (J:167314)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr4 Mutation: 46 strains or lines available

References

• Original: J:167314 Cronshaw DG, et al., An essential role of the cytoplasmic tail of CXCR4 in g-protein signaling and organogenesis. PLoS One. 2010;5(11):e15397
• All: 4 reference(s)