Slc17a6^tm1.2Edw
Targeted Allele Detail

Summary

• Symbol: Slc17a6^tm1.2Edw
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 1.2, Robert H Edwards
• MGI ID: MGI:4879031
• Synonyms: VGLUT2^delta
• Gene: Slc17a6 Location: Chr7:51271754-51320867 bp, + strand Genetic Position: Chr7, 32.78 cM, cytoband B4
• Alliance: Slc17a6^tm1.2Edw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167767
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv x C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT-flanked NeoR cassette were inserted upstream of exon 2, and a second loxP site was introduced into the 3 region of the gene. Flp-mediated recombination removed the neo cassette, and cre-mediated recombination removes exon 2. The absence of protein expression was confirmed by western blot analysis and immunohistochemistry. (J:167767)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc17a6 Mutation: 60 strains or lines available

References

• Original: J:167767 Hnasko TS, et al., Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11;65(5):643-56
• All: 4 reference(s)