Ing2^tm1.1Ccha
Targeted Allele Detail

Summary

• Symbol: Ing2^tm1.1Ccha
• Name: inhibitor of growth family, member 2; targeted mutation 1.1, Curtis C Harri
• MGI ID: MGI:4879096
• Synonyms: Ing2^-
• Gene: Ing2 Location: Chr8:48120213-48128591 bp, - strand Genetic Position: Chr8, 26.87 cM, cytoband B2
• Alliance: Ing2^tm1.1Ccha page

Testicular atrophy and semen abnormalities in Ing2^tm1.1Ccha/Ing2^tm1.1Ccha mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxp site was inserted into the first intron, followed by a neo cassette, flanked by two loxP sites. The neo cassette and the floxed exon 2 were removed by Cre-mediated recombination. (J:167311)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ing2^tm1.1Ccha

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ing2 Mutation: 16 strains or lines available

References

• Original: J:167311 Saito M, et al., Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One. 2010;5(11):e15541
• All: 1 reference(s)