Rptor^tm1.1Dmsa
Targeted Allele Detail

Summary

• Symbol: Rptor^tm1.1Dmsa
• Name: regulatory associated protein of MTOR, complex 1; targeted mutation 1.1, David M Sabatini
• MGI ID: MGI:4879103
• Synonyms: Rap^loxP, Raptor^f
• Gene: Rptor Location: Chr11:119493731-119790402 bp, + strand Genetic Position: Chr11, 83.96 cM, cytoband E2
• Alliance: Rptor^tm1.1Dmsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6 was flanked by 5' and 3' LoxP sites located 111 bp upstream and 547 bp downstream, respectively, and an FRT flanked neo cassette was inserted via homologous recombination. The neo cassette was removed by flp mediated recombination. (J:167208)

Expression

In Mice Carrying this Mutation:	9 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rptor^tm1.1Dmsa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rptor Mutation: 117 strains or lines available

References

• Original: J:167208 Sengupta S, et al., mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 2010 Dec 23;468(7327):1100-4
• All: 171 reference(s)