Crtc3^tm1Mmy
Targeted Allele Detail

Summary

• Symbol: Crtc3^tm1Mmy
• Name: CREB regulated transcription coactivator 3; targeted mutation 1, Marc R Montminy
• MGI ID: MGI:4879976
• Gene: Crtc3 Location: Chr7:80236375-80338625 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Crtc3^tm1Mmy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167211
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which encodes the CREB binding domain, was replaced with a neo cassette via homologous recombination. Quantitative PCR and immunoblot analysis confirmed the absence of expression in multiple tissues from homozygous mice. (J:167211)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtc3 Mutation: 18 strains or lines available

References

• Original: J:167211 Song Y, et al., CRTC3 links catecholamine signalling to energy balance. Nature. 2010 Dec 16;468(7326):933-9
• All: 5 reference(s)