Pld2^tm1.1Gdp
Targeted Allele Detail

Summary

• Symbol: Pld2^tm1.1Gdp
• Name: phospholipase D2; targeted mutation 1.1, Gilbert Di Paolo
• MGI ID: MGI:4880012
• Gene: Pld2 Location: Chr11:70430890-70448936 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Pld2^tm1.1Gdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166741
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. This allele is created by using either Cre-mediated recombination to remove exons 13-15 and the selection cassette or Flp-mediated recombination to remove the FRT-flanked neo cassette, followed by Cre-mediated recombination to remove exons 13 to 15. The reduction in protein expression was confirmed by western blot analysis. (J:166741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pld2 Mutation: 49 strains or lines available

References

• Original: J:166741 Oliveira TG, et al., Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci. 2010 Dec 8;30(49):16419-28
• All: 17 reference(s)