Lep^m1Yst
Chemically induced Allele Detail

Summary

• Symbol: Lep^m1Yst
• Name: leptin; mutation 1, Yau-Sheng Tsai
• MGI ID: MGI:4880027
• Synonyms: Leptin^145E
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^m1Yst page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutatgenesis induced a T to A transversion in exon 3 that results in the amino acid substitution of glutamic acid for valine at position 145 (V145E). (J:167736)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 23 strains or lines available

References

• Original: J:167736 Hong CJ, et al., ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PLoS One. 2010;5(12):e15333
• All: 1 reference(s)