Lep^m1Yst
Chemically induced Allele Detail

Summary

• Symbol: Lep^m1Yst
• Name: leptin; mutation 1, Yau-Sheng Tsai
• MGI ID: MGI:4880027
• Synonyms: Leptin^145E
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^m1Yst page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutatgenesis induced a T to A transversion in exon 3 that results in the amino acid substitution of glutamic acid for valine at position 145 (V145E). (J:167736)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Lep^m1Yst/Lep^m1Yst	C57BL/6J-Lep^m1Yst

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
adipose tissue	√
increased brown adipose tissue amount	√
increased white adipose tissue amount	√
increased total body fat amount	√
increased brown fat cell lipid droplet size	√
increased white fat cell number	√
increased white fat cell size	√
abnormal gonadal fat pad morphology	√
increased inguinal fat pad weight	√
behavior/neurological	√
abnormal eating behavior	√
cardiovascular system	√
increased heart weight	√
digestive/alimentary system	√
increased defecation amount	√
growth/size/body	√
increased heart weight	√
increased body weight	√
obese	√
increased body length	√
increased kidney weight	√
increased liver weight	√
hematopoietic system	√
increased macrophage cell number	√
homeostasis/metabolism	√
increased circulating glucose level	√
increased circulating insulin level	√
increased circulating leptin level	√
increased circulating cholesterol level	√
increased circulating triglyceride level	√
decreased body temperature	√
impaired glucose tolerance	√
insulin resistance	√
immune system	√
increased macrophage cell number	√
liver/biliary system	√
increased liver weight	√
hepatic steatosis	√
pale liver	√
renal/urinary system	√
increased kidney weight	√
polyuria	√
reproductive system	√
infertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 23 strains or lines available

References

• Original: J:167736 Hong CJ, et al., ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PLoS One. 2010;5(12):e15333
• All: 1 reference(s)