Klrd1^tm1.1Lll
Targeted Allele Detail

Summary

• Symbol: Klrd1^tm1.1Lll
• Name: killer cell lectin-like receptor, subfamily D, member 1; targeted mutation 1.1, Lewis L Lanier
• MGI ID: MGI:4880661
• Gene: Klrd1 Location: Chr6:129568745-129575738 bp, + strand Genetic Position: Chr6, 63.42 cM
• Alliance: Klrd1^tm1.1Lll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167730
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced part of exon 3 and all of exon 4. Cre-mediated recombination removed the neo cassette. The absence of the receptor heterodimers as confirmed by splenocyte labelling and sorting. (J:167730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klrd1 Mutation: 19 strains or lines available

References

• Original: J:167730 Orr MT, et al., Development and function of CD94-deficient natural killer cells. PLoS One. 2010;5(12):e15184
• All: 3 reference(s)