Fadd^tm1.1Mpa
Targeted Allele Detail

Summary

• Symbol: Fadd^tm1.1Mpa
• Name: Fas associated via death domain; targeted mutation 1.1, Manolis Pasparakis
• MGI ID: MGI:4880717
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm1.1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167475
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:167475)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 18 strains or lines available

References

• Original: J:167475 Mc Guire C, et al., Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol. 2010 Dec 15;185(12):7646-53
• All: 2 reference(s)