Igf2^tm1Snha
Targeted Allele Detail

Summary

• Symbol: Igf2^tm1Snha
• Name: insulin-like growth factor 2; targeted mutation 1, Sylvie N Hardouin
• MGI ID: MGI:4880744
• Synonyms: Igf2-P2^-
• Gene: Igf2 Location: Chr7:142204503-142220553 bp, - strand Genetic Position: Chr7, 87.99 cM
• Alliance: Igf2^tm1Snha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167738
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Alternative exon 1, including the second alternative promoter P2 upstream of it (Rr145), was replaced with a lacZ-neo cassette via homologous recombination. Real-time PCR analysis showed reduced total transcripts throughout development. However, no reduction in total protein level was detected during development. (J:167738)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2 Mutation: 28 strains or lines available

References

• Original: J:167738 Hardouin SN, et al., Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011 Jan;138(2):203-13
• All: 3 reference(s)