Il4^tm2.1Kubo
Targeted Allele Detail

Summary

• Symbol: Il4^tm2.1Kubo
• Name: interleukin 4; targeted mutation 2.1, Masato Kubo
• MGI ID: MGI:4880750
• Synonyms: HS2-KO
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm2.1Kubo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167446
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The HS2 enhancer element within intron 2 was replaced with a floxed neo cassette that was subsequently removed by cre-mediated recombination. (J:167446)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 46 strains or lines available

References

• Original: J:167446 Tanaka S, et al., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol. 2011 Jan;12(1):77-85
• All: 4 reference(s)