Rr10^tm1.1Kubo
Targeted Allele Detail

Summary

• Symbol: Rr10^tm1.1Kubo
• Name: regulatory region 10; targeted mutation 1.1, Masato Kubo
• MGI ID: MGI:4880752
• Gene: Rr10 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Rr10^tm1.1Kubo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167446
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The HS4 enhancer element downstream of the Il4 3'UTR was replaced with a floxed neomycin resistance gene cassette that was subsequently removed by cre-mediated recombination. (J:167446)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr10 Mutation: 1 strain or line available

References

• Original: J:167446 Tanaka S, et al., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol. 2011 Jan;12(1):77-85
• All: 2 reference(s)