Rr9^tm1.1Kubo
Targeted Allele Detail

Summary

• Symbol: Rr9^tm1.1Kubo
• Name: regulatory region 9; targeted mutation 1.1, Masato Kubo
• MGI ID: MGI:4880765
• Synonyms: CGRE-KO
• Gene: Rr9 Location: Chr11:53526886-53527279 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr9^tm1.1Kubo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167446
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The HS1, a conserved GATA3-response element upstream of the Il13 promoter that regulates expression of Il13 and Il4, was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:167446)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr9 Mutation: 1 strain or line available

Notes

ES cell line = B6JN/1 mouse embryonic stem cells, derived from a (C57BL6/JJcl) x (C57BL6/NJcl) embryo

References

• Original: J:167446 Tanaka S, et al., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol. 2011 Jan;12(1):77-85
• All: 4 reference(s)