Fbxo41^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Fbxo41^{tm1(KOMP)Vlcg}
• Name: F-box protein 41; targeted mutation 1, Velocigene
• MGI ID: MGI:4881288
• Gene: Fbxo41 Location: Chr6:85446556-85479976 bp, - strand Genetic Position: Chr6, 37.48 cM
• Alliance: Fbxo41^{tm1(KOMP)Vlcg} page
• IMPC: Fbxo41 gene page

Mutation origin

• Mutant Cell Lines: 15414A-D5, 15414A-E4, 15414A-F3, 15414A-F7, 15414A-H12
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 11734bp between positions 85449970-85461703 of Chromosome 6 (Build GRCm39). The lacZ reporter replaced the gene. Western blot analysis confirmed the absence of protein expression in P16 cerebellum. (J:136110, J:222558)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Fbxo41 Mutation: 33 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)