Fxn^tm1.1Pand
Targeted Allele Detail

Summary

• Symbol: Fxn^tm1.1Pand
• Name: frataxin; targeted mutation 1.1, Massimo Pandolfo
• MGI ID: MGI:4881494
• Synonyms: Fxn^GAA230
• Gene: Fxn Location: Chr19:24238817-24257969 bp, - strand Genetic Position: Chr19, 19.39 cM, cytoband C1
• Alliance: Fxn^tm1.1Pand page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109164
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Mice carrying the Fxn^tm1Pand allele were crossed with mice carrying the Meox2^tm1(cre)Sor allele to remove the neomycin cassette, leaving an insertion of a GAA230 repeat expansion. (J:109164)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fxn Mutation: 42 strains or lines available

References

• Original: J:109164 Miranda CJ, et al., Frataxin knockin mouse. FEBS Lett. 2002 Feb 13;512(1-3):291-7
• All: 10 reference(s)