Ssr3^tm1Ryn
Targeted Allele Detail

Summary

• Symbol: Ssr3^tm1Ryn
• Name: signal sequence receptor, gamma; targeted mutation 1, Ryuichi Nishinakamura
• MGI ID: MGI:4881708
• Synonyms: Ssr3^tm1Ryni, Trap-gamma^LacZ
• Gene: Ssr3 Location: Chr3:65287078-65299974 bp, - strand Genetic Position: Chr3, 30.15 cM
• Alliance: Ssr3^tm1Ryn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167832
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 from before the initiation codon was replaced with a lox71-LacZ-pA-frt-Pro-Neo-frt-loxPpA cassette via homologous recombinaation. RT-PCR and western blot analysis confirmed the absence of expression in homozygous E18.5 embryos. (J:167832)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssr3 Mutation: 6 strains or lines available

References

• Original: J:167832 Yamaguchi YL, et al., Translocon-associated protein subunit Trap-gamma/Ssr3 is required for vascular network formation in the mouse placenta. Dev Dyn. 2011 Feb;240(2):394-403
• All: 1 reference(s)