Ackr3^tm1.1Twb
Targeted Allele Detail

Summary

• Symbol: Ackr3^tm1.1Twb
• Name: atypical chemokine receptor 3; targeted mutation 1.1, Timothy Behrens
• MGI ID: MGI:4881712
• Synonyms: Ackr3^tm1.1Dsr, Cxcr7^-
• Gene: Ackr3 Location: Chr1:90131702-90143446 bp, + strand Genetic Position: Chr1, 45.28 cM
• Alliance: Ackr3^tm1.1Twb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167833
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:167833)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ackr3 Mutation: 34 strains or lines available

References

• Original: J:167833 Yu S, et al., The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011 Feb;240(2):384-93
• All: 3 reference(s)