Wls^tm1.1Whsu
Targeted Allele Detail

Summary

• Symbol: Wls^tm1.1Whsu
• Name: wntless WNT ligand secretion mediator; targeted mutation 1.1, Wei Hsu
• MGI ID: MGI:4881718
• Synonyms: Gpr177Fx
• Gene: Wls Location: Chr3:159545309-159644300 bp, + strand Genetic Position: Chr3, 82.65 cM
• Alliance: Wls^tm1.1Whsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167835
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 3 floxed. (J:167835)

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wls Mutation: 38 strains or lines available

References

• Original: J:167835 Fu J, et al., Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn. 2011 Feb;240(2):365-71
• All: 17 reference(s)