Triobp^tm1Tbf
Targeted Allele Detail

Summary

• Symbol: Triobp^tm1Tbf
• Name: TRIO and F-actin binding protein; targeted mutation 1, Thomas B Friedman
• MGI ID: MGI:4881773
• Synonyms: Triobp^deltaexon8
• Gene: Triobp Location: Chr15:78831924-78890069 bp, + strand Genetic Position: Chr15, 37.7 cM
• Alliance: Triobp^tm1Tbf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167947
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified isoform(s), Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Nearly all of exon 8 was replaced by a nlacZ reporter cassette and a floxed neo cassette, which was removed by cre-mediated recombination. The absence of isoform 5 transcript and isoform 4/5 proteins in the inner ear was confirmed by RT-PCR and western blot analysis respectively. Isoform 1 is retained. (J:167947)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Triobp Mutation: 74 strains or lines available

References

• Original: J:167947 Kitajiri S, et al., Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28;141(5):786-98
• All: 4 reference(s)