Cnot3^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Cnot3^tm1Pngr
• Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:4881781
• Synonyms: not3^-
• Gene: Cnot3 Location: Chr7:3648267-3664108 bp, + strand Genetic Position: Chr7, 2.1 cM
• Alliance: Cnot3^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167954
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-9 were replaced with a PGK-neomycin selection cassette in reverse orientation. No mRNA was detected by RT-PCR in homozygous blastocysts nor was any protein detected by immunostaining. (J:167954)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot3 Mutation: 35 strains or lines available

References

• Original: J:167954 Neely GG, et al., A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010 Apr 2;141(1):142-53
• All: 1 reference(s)